| Projects | |
| A1) |
Selective
histamine H2 receptor agonists |
| A2) |
Selective
histamine H1 receptor agonists |
| A3) |
Chiral
histamine H1 and H2
receptor agonists: solid phase synthesis of branched histidine and
histamine analogues |
| A4) |
Structure
function analysis of human and mouse histamine H4
receptors |
| A5) |
Partial
agonists of serotonin receptors (5-HT2A, 5-HT2B, |
| A6) |
Molecular
and cellular analysis of the histamine H4-receptor |
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| B1) |
Helical
α,β-foldamers as ligands for neuropeptide Y receptors |
| B2) |
Design,
synthesis and pharmacological activity of non-peptidic selective
neuropeptide Y-receptor antagonists |
| B3) |
Synthesis,
pharmacological activity and binding properties of bivalent NPY Y1
antagonists |
| B4) |
G-Protein
coupled receptors as targets for cell recognition in drug targeting |
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|
| C1) |
NMR-aided
design of drugs, characterization and modulation of the
protein-protein-interaction in membrane-associated signal transduction |
| C2) |
Molecular
Modeling of G-Protein coupled receptors |
| C3) |
Inhibition
of membrane receptor mediated gene activation by blockade of nuclear
receptors |
| C4) |
Label-free
detection of ligand binding to membrane receptors |
| C5) |
Development
of fluorescence-based methods for the determination of affinity and
activity of ligands of GPCRs |
|
Determination
of affinity and activity of GPCR ligands by measuring fluorescence
intensities |
|
Luminescence
labelling of peptides of the NPY family with terpyridine-lanthanide
complexes and determination of binding properties by time-resolved
analysis
|
| C6) |
Receptor regulation by NO/cGMP-Signalling Contact and download pdf-file  Open position (scholarship) |
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Note: Some additional projects (not listed above), which were started in the course of the first grant period of the GRK 760 (April 2002 - March 2005), are now out of the focus of the research program and will be discontinued after completion the PhD thesis of the respective graduates. |
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| graduate_college@medicinal-chemistry.de | |